Olmesartan Medoxomil Powder CAS 144689-63-4
Synonym:Olmesartan Medoxomi;Olmesartan MedoxomiI;OMST;OLMESARTAN MEDOXOMIL USP ORGANIC CHEMICA;cs-866;Olmesartan;Olmetec;1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-
CAS NO.:144689-63-4
EINECS NO.:604-433-1
Molecular Formula:C29H30N6O6
Purity & Grade: 99%; Medicine grade
MOQ & Package: 25g; Package according to demand
Lead Time: 7-15 days
Store & Shelf life: Cool & dry place; 24 months
Description/kawalan
| White to off-white crystalline powder | ||
| DMSO: soluble20mg/mL, clear | ||
| Purity 99% | ||
| 1.4±0.1 g/cm3 | ||
| 804.2±75.0 degree at 760 mmHg | ||
| 180 degree | ||
| C29H30N6O6 | ||
| 558.585 | ||
| 440.2±37.1 degree | ||
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Density 1.4±0.1 g/cm3
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Boiling point is 804.2±75.0 degree at 760 mmHg.
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Melting point 180 degree
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The molecular formula is C29H30N6O6.
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Molecular weight 558.585
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Flash point 440.2±37.1 degree
1.is a sartan antihypertensive product. It overcomes the disadvantages of angiotensin-converting enzyme inhibitors (ACEI) and retains the advantages of ACEI. Its effect is similar to ACEI products, but it does not cause dry cough, rash and angioneurotic edema, and has fewer adverse reactions and is well tolerated by patients. It has a good effect on the treatment of mild and moderate hypertension and is widely popular in clinic.
2.has effective antihypertensive effect. After use, it is completely de-esterified in the wall of the small intestine and converted to the active metabolite olmesartan. Olmesartan is a selective non-peptide angiotensin II receptor antagonist, which blocks the vasoconstriction effect of angiotensin II by selectively blocking the binding of angiotensin II to vascular smooth muscle AT1 receptor.
3.Common sartan antihypertensive products: valsartan, Irbesartan, Telmisartan, Candesartan siloxetate, Ipsartan, Tazobactam, olmesartan siloxetate.
1.
2. is a precursor to the synthesis of imidazole derivatives and has antihypertensive effect. After hydrolysis, olmesartan medoxomil is converted to olmesartan. Olmesartan selectively binds angiotensin type 1 (AT1) receptors in vascular smooth muscle and adrenal angiotensin II, thereby competing for angiotensin II binding to the receptor. This prevents angiotensin II-induced vasoconstriction and reduces aldosterone production, thereby preventing aldosterone-stimulated sodium retention and potassium excretion.
3. An angiotensin II type 1 receptor blocker for controlling hypertension.
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3-7 days |
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Suitable for under 50kg. |
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7-15 days |
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Suitable for more than 50kg. |
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15-60 days |
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Suitable for more than 500kg. |
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